Understanding how a new antiviral response pathway works against viruses
Official title: Characterization of a Novel FACT-ETS-1 Antiviral Response Pathway and Identification of RNA Virus-Encoded Antagonists of this Host Response
Funded at Ut Southwestern Medical Center · NIH-10994665 · Data updated 2026-11-12
This study is looking at a new way our body's cells fight off certain viruses, which could help us find better treatments for viral infections and improve how our immune systems work.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | December 5, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $198,850 |
| NIH project number | 5R21AI180551-02 |
| Project ID | NIH-10994665 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with viral infections or those at high risk for such infections.
✕Less likely to help
Patients with non-viral infections or those not affected by the specific viruses studied may not receive any benefit from this research.
What this research studies
This research investigates a newly discovered antiviral response pathway in human cells called the FACT-ETS-1 Antiviral Response (FEAR) Pathway, which helps to limit the replication of certain viruses, including vaccinia virus and vesicular stomatitis virus. The study focuses on how this pathway is activated and the role of specific proteins involved in the immune response to viral infections. By examining the interactions between these proteins and viral antagonists, the research aims to uncover new mechanisms of antiviral immunity that could lead to improved treatments. Patients may benefit from insights gained into how their immune systems can better combat viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing antiviral immunity in patients.
How similar studies have gone: Other research has shown success in understanding antiviral pathways, but the specific FEAR pathway is a novel area of investigation.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Gammon, Don Brad — Ut Southwestern Medical Center
- Study coordinator: Gammon, Don Brad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.