Understanding how a natural hormone affects the pancreas in diabetes
The effect of endogenous GLP-1 secretion on islet function in vivo
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-11034407
This project explores how a natural hormone called GLP-1, made in your body, helps your pancreas manage blood sugar, especially for people with prediabetes and type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11034407 on ClinicalTrials.gov |
What this research studies
Our bodies naturally produce a hormone called GLP-1, which plays a key role in how the pancreas releases insulin and glucagon to control blood sugar. We want to understand if problems with this natural GLP-1 system contribute to prediabetes and type 2 diabetes. We will use special medications to temporarily block or boost GLP-1's effects to see how it changes the pancreas's function. This work also looks at how weight loss and a specific genetic factor might influence this important hormone system.
Who could benefit from this research
Good fit: Ideal candidates for future related opportunities might include individuals with prediabetes, type 2 diabetes, or those interested in understanding the genetic factors influencing diabetes.
Not a fit: Patients whose diabetes is not related to GLP-1 pathways or islet function may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat type 2 diabetes by targeting the body's natural GLP-1 system.
How similar studies have performed: Previous work has shown that GLP-1 plays a significant role in human islet function, and this project builds upon those findings to explore specific mechanisms in prediabetes and type 2 diabetes.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VELLA, ADRIAN — MAYO CLINIC ROCHESTER
- Study coordinator: VELLA, ADRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Brittle Diabetes Mellitus