Understanding how a natural hormone affects the pancreas in diabetes
Official title: The effect of endogenous GLP-1 secretion on islet function in vivo
Funded at Mayo Clinic Rochester · NIH-11034407 · Data updated 2026-11-12
This project explores how a natural hormone called GLP-1, made in your body, helps your pancreas manage blood sugar, especially for people with prediabetes and type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $742,934 |
| NIH project number | 2R01DK126206-06 |
| Project ID | NIH-11034407 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for future related opportunities might include individuals with prediabetes, type 2 diabetes, or those interested in understanding the genetic factors influencing diabetes.
✕Less likely to help
Patients whose diabetes is not related to GLP-1 pathways or islet function may not directly benefit from this specific line of inquiry.
What this research studies
Our bodies naturally produce a hormone called GLP-1, which plays a key role in how the pancreas releases insulin and glucagon to control blood sugar. We want to understand if problems with this natural GLP-1 system contribute to prediabetes and type 2 diabetes. We will use special medications to temporarily block or boost GLP-1's effects to see how it changes the pancreas's function. This work also looks at how weight loss and a specific genetic factor might influence this important hormone system.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat type 2 diabetes by targeting the body's natural GLP-1 system.
How similar studies have gone: Previous work has shown that GLP-1 plays a significant role in human islet function, and this project builds upon those findings to explore specific mechanisms in prediabetes and type 2 diabetes.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Vella, Adrian — Mayo Clinic Rochester
- Study coordinator: Vella, Adrian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.