Understanding how a natural compound affects blood vessel aging
Cystathionine Gamma Lyase (CSE) and Hydrogen Sulfide Regulation of Vascular Aging
This project explores how a natural substance called hydrogen sulfide helps keep our blood vessels healthy as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project ID | NIH-11143031 on NIH RePORTER |
What this research studies
As we age, our blood vessels can change, increasing the risk for heart and blood vessel diseases. This project looks into how a specific natural compound, hydrogen sulfide, and the enzyme that makes it, called CSE, might protect our blood vessels from these age-related changes. We want to understand the detailed ways these compounds work and how their levels might affect blood vessel health over time. The goal is to uncover new information about how our bodies regulate blood vessel health as we age.
Who could benefit from this research
Good fit: This foundational research does not currently involve patient participation, but future studies may seek individuals interested in vascular aging and cardiovascular health.
Not a fit: Patients not interested in or affected by vascular aging or cardiovascular diseases would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to protect blood vessels and prevent heart disease as people get older.
How similar studies have performed: This project aims to reveal novel information about the specific role of CSE/H2S signaling in vascular remodeling during aging, building on existing knowledge but exploring new regulatory mechanisms.
Where this research is happening
Shreveport, United States
- Louisiana State Univ Hsc Shreveport — Shreveport, United States (Active)
Researchers
- Principal investigator: Kolluru, Gopi K — Louisiana State Univ Hsc Shreveport
- Study coordinator: Kolluru, Gopi K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.