Understanding how a natural body process affects bone marrow stem cells and bone health as we age
PROJECT 3 - Kynurenine-AhR Signaling Effects on Mitophagy and Senescence with Age in Bone Marrow Stem Cells
['FUNDING_P01'] · AUGUSTA UNIVERSITY · NIH-11103317
This research explores how a natural pathway in our bodies, called the kynurenine pathway, contributes to aging-related problems like weak bones and stem cell changes.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-11103317 on ClinicalTrials.gov |
What this research studies
Our bodies have a natural process involving a substance called tryptophan, which breaks down into kynurenine. Recent findings suggest that this kynurenine pathway becomes more active with age and can harm bone marrow stem cells, leading to weaker bones and muscle loss. This project aims to understand exactly how elevated kynurenine levels affect these stem cells, causing them to age prematurely and lose their ability to form new bone. By studying these changes, we hope to uncover new ways to protect bone health as people get older.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the biological processes behind aging, bone loss, and stem cell health.
Not a fit: Patients seeking immediate treatment for their conditions will not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or strategies to prevent age-related bone loss and improve the health of bone marrow stem cells.
How similar studies have performed: This research builds on recent discoveries by the group identifying the kynurenine pathway as a novel mechanism in age-associated musculoskeletal complications.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FULZELE, SADANAND TUKDOJI — AUGUSTA UNIVERSITY
- Study coordinator: FULZELE, SADANAND TUKDOJI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.