Understanding how a molecule called succinate affects metabolism and inflammation in the body
Defining mechanisms of extracellular succinate regulation over metabolic tissue function
This research explores how a molecule called succinate, found outside cells, influences our body's metabolism and inflammation, especially in conditions like obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11124121 on NIH RePORTER |
What this research studies
Our bodies produce a molecule called succinate, which can signal between cells and affect how our metabolism works and whether we experience inflammation. We've learned that when brown fat activity is low, or when people eat a Western-style diet, succinate can build up in the liver, leading to inflammation and scarring. This project aims to understand whether succinate acts in a helpful or harmful way, depending on how long tissues are exposed to it. By studying how succinate affects different cell types over time, we hope to uncover the specific molecular pathways involved. This knowledge is crucial for developing new ways to manage metabolic health.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit future patients with metabolic disorders, obesity, or chronic inflammation.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for treating metabolic diseases, obesity-related inflammation, and tissue scarring.
How similar studies have performed: This project builds upon previous discoveries by the research team, which identified both protective and harmful roles for succinate in metabolic health.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Chouchani, Edward Thomas — Dana-Farber Cancer Inst
- Study coordinator: Chouchani, Edward Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.