Understanding how a molecule called peroxynitrite affects brain blood vessels in Alzheimer's disease.
Peroxynitrite is a Molecular Determinant of Impaired Microvascular Energetics in Alzheimer's Disease
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11134541
This project explores how a specific molecule impacts the tiny blood vessels in the brain, which might contribute to memory problems in people with Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11134541 on ClinicalTrials.gov |
What this research studies
Our brains rely on tiny blood vessels to deliver energy, and in Alzheimer's disease, these vessels don't work as well. This project looks at how the energy-producing parts of cells, called mitochondria, in these brain blood vessels are affected in Alzheimer's. We are particularly interested in a molecule called peroxynitrite, which seems to play a role in how these vessels function differently in males and females as they age. By understanding these differences, we hope to uncover new ways to protect brain health.
Who could benefit from this research
Good fit: This foundational research uses animal models and does not currently involve direct human participation.
Not a fit: Patients not experiencing Alzheimer's disease or related cognitive decline would not be the focus of future treatments developed from this research.
Why it matters
Potential benefit: If successful, this work could identify new targets for treatments that protect brain blood vessels and improve cognitive function in individuals with Alzheimer's disease.
How similar studies have performed: While the specific role of peroxynitrite in microvascular energetics in AD is a novel focus, previous research has highlighted the importance of mitochondrial health and microvascular function in neurodegenerative diseases.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KATAKAM, PRASAD V — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: KATAKAM, PRASAD V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease