Understanding how a molecule called heme controls aging
Lifespan Regulation by Inter-Organellar Heme Signaling
['FUNDING_R01'] · GEORGIA INSTITUTE OF TECHNOLOGY · NIH-11132953
This project explores how a molecule called heme influences the aging process and lifespan in cells and simple animals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGIA INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11132953 on ClinicalTrials.gov |
What this research studies
Researchers are looking into how a molecule called heme, which is important for many body functions, might also act as a signal that affects how we age. Previous findings suggest that lower levels of heme are linked to signs of aging, like problems with energy production and increased stress in cells. Interestingly, early work shows that reducing heme can actually extend life in yeast and worms. This project aims to uncover the specific ways heme signals within and between different parts of cells and organs to control lifespan.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to understand basic biological processes relevant to anyone interested in healthy aging.
Not a fit: Patients seeking immediate treatments or clinical interventions for aging-related conditions will not directly benefit from this early-stage basic science.
Why it matters
Potential benefit: If successful, this work could reveal new ways to understand and potentially influence the aging process and extend healthy lifespan.
How similar studies have performed: While the role of heme as a protein cofactor is well-known, its function as a dynamic signaling molecule in aging is a newer area of exploration, with promising preliminary findings in model organisms.
Where this research is happening
ATLANTA, UNITED STATES
- GEORGIA INSTITUTE OF TECHNOLOGY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REDDI, AMIT RAM — GEORGIA INSTITUTE OF TECHNOLOGY
- Study coordinator: REDDI, AMIT RAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.