Understanding how a liver enzyme affects drug metabolism
Carboxylesterase 1 Plasma Biomarker for Precision Pharmacotherapy
This study is looking at how a liver enzyme called CES1 affects how well certain medications, like enalapril, work for you, and it involves collecting blood samples to help find ways to tailor treatments to individual needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10908576 on NIH RePORTER |
What this research studies
This research investigates the role of Carboxylesterase 1 (CES1), a key enzyme in the liver that metabolizes various medications and toxins. By analyzing plasma samples, the study aims to identify how variations in CES1 levels can influence the effectiveness and safety of drugs like enalapril. The research will correlate plasma CES1 protein concentrations with drug metabolism outcomes, potentially leading to more personalized medication strategies. Patients may be involved in providing blood samples to help establish these important biomarkers.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals who are prescribed medications metabolized by CES1, particularly those taking enalapril.
Not a fit: Patients who do not take medications metabolized by CES1 or those with no variations in CES1 function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer drug therapies tailored to individual metabolic profiles.
How similar studies have performed: Previous research has shown promising results in using plasma biomarkers to predict drug metabolism, indicating that this approach has potential for success.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Zhu, Haojie — University of Michigan at Ann Arbor
- Study coordinator: Zhu, Haojie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.