Understanding how a key protein, RORγ, works in the body
Quantifying and modeling ligand-dependent control of RORγ dynamics via structural proteomics
This work helps us understand how a protein called RORγ controls important body processes like metabolism and immune responses, which could lead to new medicines for various diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11139416 on NIH RePORTER |
What this research studies
Our bodies have special proteins called nuclear receptors that respond to small molecules and control many essential functions, including how we use sugar and fat, grow bones, and fight off infections. This project focuses on a specific nuclear receptor, RORγ, which comes in two forms: one that is widely found in the body and another that is crucial for immune cells that fight tumors. By understanding how RORγ works at a detailed level, we can learn how to better control its activity. This knowledge is key to developing new treatments for a range of human diseases.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future clinical applications may benefit individuals with metabolic disorders, immune-related conditions, or specific cancers where RORγ plays a role.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this foundational understanding of RORγ could lead to the development of new medications that target this protein to treat conditions like metabolic disorders, bone diseases, and certain cancers.
How similar studies have performed: Our lab has a history of developing synthetic molecules and analyzing the structure and function of similar proteins, building on existing knowledge in the field of nuclear receptors.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Griffin, Patrick Robert — University of Florida
- Study coordinator: Griffin, Patrick Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.