Understanding how a key protein influences gene activity and cell growth
A new paradigm of general transcription factor TFIIB functionality in termination and promoter directionality
This study is looking at a protein called TFIIB to see how it helps control the process of turning genes on and off, which is important for how our cells grow and develop, and it could help us understand diseases that happen when this process goes wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11086658 on NIH RePORTER |
What this research studies
This research investigates the role of the general transcription factor TFIIB in regulating gene transcription, particularly its functions in both the initiation and termination phases. By examining how TFIIB interacts with other factors involved in gene expression, the study aims to uncover its significance in cellular processes such as proliferation and differentiation. The research employs advanced techniques like chromatin immunoprecipitation coupled with sequencing (ChIP-seq) to analyze these interactions at a molecular level. Insights gained from this research could enhance our understanding of various diseases linked to transcriptional misregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene expression abnormalities, such as certain cancers or developmental disorders.
Not a fit: Patients with conditions unrelated to transcriptional regulation or those not experiencing gene expression-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by transcriptional dysregulation.
How similar studies have performed: Previous research has shown promising results in understanding the roles of transcription factors in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Ansari, Athar Imtiaz — Wayne State University
- Study coordinator: Ansari, Athar Imtiaz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.