Understanding how a key protein called MIF works in inflammation
Unraveling the Allosteric Mechanism of Macrophage Migration Inhibitory Factor with Molecular Resolution
['FUNDING_R01'] · BROWN UNIVERSITY · NIH-11143179
This project aims to understand how a protein called MIF contributes to inflammation, which could help us find new ways to treat conditions like asthma.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11143179 on ClinicalTrials.gov |
What this research studies
Our bodies have a protein called Macrophage Migration Inhibitory Factor (MIF) that plays a big role in inflammation, a process involved in many diseases. We want to learn exactly how MIF's structure allows it to cause inflammation and interact with other parts of the body. By studying how tiny changes in MIF's structure affect its actions, we hope to uncover its secrets. This knowledge is crucial for designing new medicines that can specifically target MIF to reduce harmful inflammation.
Who could benefit from this research
Good fit: This foundational research is for future patients who suffer from inflammatory conditions, including those like asthma, who could benefit from new therapies.
Not a fit: Patients will not receive direct benefit from this basic science project, as it focuses on understanding disease mechanisms rather than immediate treatment.
Why it matters
Potential benefit: If successful, this work could lead to the development of new, more effective treatments for inflammatory diseases by targeting the MIF protein.
How similar studies have performed: This project builds upon recent discoveries and preliminary data about how MIF's structure influences its function, suggesting a promising new direction for research.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LISI, GEORGE — BROWN UNIVERSITY
- Study coordinator: LISI, GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.