Understanding how a key protein called IL-6 behaves in lung cells during viral infections
Silencer-enhancer transition dysregulates interleukin-6 in mucosal epithelial cell plasticity
This project aims to understand how a protein called IL-6 is controlled in lung cells during respiratory viral infections like the flu or common cold, helping us learn how to better manage inflammation.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-11137707 on NIH RePORTER |
What this research studies
Respiratory viruses such as the flu, common cold, and RSV can cause inflammation and damage in the lungs. A protein called IL-6 plays a crucial role in fighting these viruses, but too much IL-6 can make symptoms worse and prolong illness. This project focuses on how IL-6 is regulated in human lung cells, specifically looking at a control switch that can either quiet or boost its production. By understanding this switch, we hope to discover new ways to control the body's response to viral infections and prevent severe lung issues. This work uses human lung cell samples to study these important biological processes.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but it focuses on understanding processes relevant to anyone affected by respiratory viral infections.
Not a fit: Patients who do not experience respiratory viral infections or related lung inflammation would likely not see direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to control the body's inflammatory response to respiratory viruses, potentially reducing severe symptoms and lung damage.
How similar studies have performed: This project builds on preliminary data identifying a novel dual-function regulatory element for IL-6, suggesting a new angle in understanding viral responses.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Yang, Jun — University of Texas Med Br Galveston
- Study coordinator: Yang, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.