Understanding how a key process in our cells works and its role in health
Mechanisms and biological functions of SPOUT methyltransferases
This research explores how tiny molecules called tRNAs are modified in our cells and how these changes affect our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11176354 on NIH RePORTER |
What this research studies
Our bodies rely on a fundamental process called protein synthesis, where genetic instructions are turned into proteins that do all the work in our cells. Transfer RNAs, or tRNAs, are essential adaptors in this process, and specific chemical changes, like methylation, are common on them. When these tRNA modifications go wrong, they can lead to various human diseases. This project aims to uncover the exact ways certain enzymes modify tRNAs and how these modifications impact important cellular functions, using a combination of genetic, biochemical, and structural approaches.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this knowledge could benefit individuals with diseases linked to tRNA modification defects.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a human clinical trial would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the root causes of certain human diseases linked to tRNA dysfunction and potentially open doors for new treatment strategies.
How similar studies have performed: While a detailed understanding of these specific enzymes is still emerging, other studies have shown that defects in tRNA modification can indeed lead to various human diseases.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Jackman, Jane Elizabeth — Ohio State University
- Study coordinator: Jackman, Jane Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.