Understanding how a key Parkinson's protein spreads in the brain
Structural basis and physiological consequences of alpha-Synuclein binding to neurexin 1beta
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11127766
This project looks at how a protein called alpha-Synuclein, which is linked to Parkinson's disease, moves from one brain cell to another.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11127766 on ClinicalTrials.gov |
What this research studies
Parkinson's disease is characterized by clumps of a protein called alpha-Synuclein, known as Lewy bodies, in the brain. We believe that the spread of these toxic alpha-Synuclein forms from cell to cell might be how the disease gets worse. Our team recently found that a protein on brain cells, called neurexin 1beta, helps alpha-Synuclein get inside cells. This research aims to understand exactly how alpha-Synuclein connects with neurexin 1beta and how this interaction leads to its spread. By uncovering these details, we hope to learn more about how Parkinson's progresses.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but focuses on understanding the disease mechanisms relevant to individuals with Parkinson's disease.
Not a fit: Patients seeking immediate new treatments or clinical trial opportunities would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new targets for therapies that stop the spread of harmful proteins in Parkinson's disease.
How similar studies have performed: While the specific interaction is a new discovery by this lab, other research supports the idea that alpha-Synuclein can spread between cells.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RHOADES, ELIZABETH — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: RHOADES, ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.