Understanding how a key liver enzyme affects blood sugar levels
Official title: Structure and Mechanism of the Glucose-6-Phosphatase Catalytic Subunit 1
Funded at Vanderbilt University · NIH-10812000 · Data updated 2026-11-12
This study is looking at a key enzyme in the liver that helps control blood sugar levels, to understand how changes in this enzyme can affect diabetes and other related health issues, which could help patients find better ways to manage their conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | September 21, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $338,889 |
| NIH project number | 1R01GM149686-01A1 |
| Project ID | NIH-10812000 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with diabetes or glycogen storage disease type 1a.
✕Less likely to help
Patients with unrelated metabolic disorders or those not affected by glucose metabolism issues may not benefit from this research.
What this research studies
This research investigates the structure and function of the glucose-6-phosphatase catalytic subunit 1 (G6PC1), an important enzyme in the liver that regulates glucose production. By using advanced techniques like 3D modeling and biophysical methods, the study aims to uncover how this enzyme's activity is linked to diabetes and other metabolic disorders. The research will explore how mutations in G6PC1 can lead to conditions like glycogen storage disease type 1a, characterized by severe low blood sugar. Patients may benefit from insights gained about how to better manage or treat diabetes and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetes and related metabolic disorders.
How similar studies have gone: Previous research has shown promise in understanding similar enzymes and their roles in metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Claxton, Derek P — Vanderbilt University
- Study coordinator: Claxton, Derek P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.