Understanding how a key factor controls stem cells in the colon
Investigating a master regulator of large intestine stem cells
This study is looking at a special protein called SATB2 to understand how it helps colon cells grow and stay healthy, which could give us important clues about conditions like colorectal cancer and ulcerative colitis that affect the colon.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10892933 on NIH RePORTER |
What this research studies
This research investigates the role of SATB2, a crucial molecular regulator, in the biology of the colon. By studying how SATB2 influences the differentiation and maintenance of colonic stem cells, the research aims to uncover the molecular mechanisms that distinguish the colon from the small intestine. The approach includes advanced techniques like ChIP sequencing to analyze gene expression and cellular composition in the colonic epithelium. This work could provide insights into diseases like colorectal cancer and ulcerative colitis, which are linked to colon health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be at risk for or currently suffering from colonic diseases.
Not a fit: Patients with conditions unrelated to colonic health or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating colorectal diseases.
How similar studies have performed: Other research has shown success in understanding stem cell regulation in different tissues, making this approach promising yet still novel in the context of the colon.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Rafii, Shahin — Weill Medical Coll of Cornell Univ
- Study coordinator: Rafii, Shahin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.