Understanding how a key enzyme regulates protein functions in cells
Official title: Structural insights into the functional regulation of O-GlcNAcase
Funded at University of Wisconsin-Madison · NIH-11032860 · Data updated 2026-11-12
This study is looking at a special enzyme called O-GlcNAcase, which helps change proteins in our cells, to understand how it works and how it might be linked to diseases like cancer and neurodegeneration, with the hope that this knowledge could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | February 15, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $295,577 |
| NIH project number | 5R01GM152998-02 |
| Project ID | NIH-11032860 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers or neurodegenerative diseases linked to OGA dysfunction.
✕Less likely to help
Patients with conditions unrelated to OGA or those not affected by cancer or neurodegeneration may not benefit from this research.
What this research studies
This research focuses on the enzyme O-GlcNAcase (OGA), which plays a crucial role in modifying proteins within cells. By investigating the structure and function of OGA, the research aims to uncover how it interacts with various protein substrates, particularly in the context of diseases like cancer and neurodegeneration. The study employs advanced structural biology techniques to reveal the enzyme's binding mechanisms and regulatory roles, which could lead to new therapeutic strategies. Patients may benefit from insights gained about OGA's role in disease progression and treatment.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and safer therapies for diseases associated with OGA dysfunction.
How similar studies have gone: Other research has shown promising results in targeting similar enzymes for therapeutic purposes, indicating a potential for success in this area.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Jiang, Jiaoyang — University of Wisconsin-Madison
- Study coordinator: Jiang, Jiaoyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.