Understanding how a key enzyme regulates acid balance in cells
Structure and Regulatory Mechanisms of the Vacuolar ATPase
This study is looking at a special enzyme called V-ATPase that helps keep our cells balanced and healthy, and it aims to understand how changes in this enzyme might be linked to diseases like cancer and diabetes, which could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-11066512 on NIH RePORTER |
What this research studies
This research investigates the vacuolar ATPase (V-ATPase), an essential enzyme that helps maintain acid-base balance in cells. By examining its structure and regulatory mechanisms, the research aims to uncover how this enzyme functions in various cellular processes, including bone remodeling and neurotransmitter release. The study will explore how changes in V-ATPase activity can lead to diseases such as cancer and diabetes, providing insights into potential therapeutic targets. Patients may benefit from a better understanding of these conditions and the development of new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions such as osteopetrosis, diabetes, male infertility, neurodegeneration, or cancer.
Not a fit: Patients with conditions unrelated to V-ATPase function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases linked to V-ATPase dysfunction, improving patient outcomes.
How similar studies have performed: Previous research has shown that understanding enzyme mechanisms can lead to significant advancements in treating related diseases, indicating potential success for this approach.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Wilkens, Stephan — Upstate Medical University
- Study coordinator: Wilkens, Stephan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.