Understanding how a key enzyme protects cells from damage caused by reactive oxygen species
Deciphering the Enzymatic Mechanism of Superoxide Dismutase
This study is looking at how a special enzyme called manganese superoxide dismutase (MnSOD) helps protect our cells from damage caused by stress, and it aims to uncover its 3D structure to better understand how it works, which could help us learn more about keeping our cells healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11071960 on NIH RePORTER |
What this research studies
This research investigates the enzymatic mechanism of manganese superoxide dismutase (MnSOD), which plays a crucial role in protecting cells from oxidative stress. By utilizing advanced neutron crystallography techniques, the study aims to reveal the detailed 3D structure of MnSOD, including the positioning of protons and the interactions with metal ions. This understanding could lead to insights into how MnSOD functions in cellular signaling and redox homeostasis, which are vital for maintaining healthy cellular environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions associated with oxidative stress, including certain cancers and cardiovascular diseases.
Not a fit: Patients with conditions unrelated to oxidative stress or those who do not have a significant oxidative stress component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to oxidative stress, such as cancers and cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of oxidative stress regulation, making this approach both relevant and potentially impactful.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Borgstahl, Gloria — University of Nebraska Medical Center
- Study coordinator: Borgstahl, Gloria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.