Understanding how a key enzyme helps the body fight viral infections
Mechanisms of Enzyme Regulation by Viperin in the Cellular Antiviral Response
This study is looking at how a special enzyme called viperin helps our body fight off viruses, like HIV and hepatitis C, by understanding how it works with other proteins, which could lead to new treatments to boost our immune response.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11123580 on NIH RePORTER |
What this research studies
This research investigates the role of viperin, an enzyme that is crucial in the body's antiviral response. By examining how viperin regulates various cellular metabolic pathways during viral infections, the research aims to uncover mechanisms that limit viral replication. The approach involves studying the biochemical interactions of viperin with viral and cellular proteins, which could lead to the development of new antiviral therapies. Patients may benefit from insights gained about enhancing the immune response against viruses like HIV and hepatitis C.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with viruses such as HIV or hepatitis C, or those at risk of such infections.
Not a fit: Patients with viral infections not related to the mechanisms being studied, or those with non-viral diseases, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective antiviral treatments for patients suffering from viral infections.
How similar studies have performed: Previous research has shown promising results in understanding the antiviral properties of enzymes like viperin, indicating potential for success in this area.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Marsh, E Neil — University of Michigan at Ann Arbor
- Study coordinator: Marsh, E Neil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.