Understanding how a key enzyme affects hormone production and cancer treatment
Dynamics and Interactions of Cytochrome P450 19A1
This study is looking at how a specific enzyme helps make estrogen from other hormones, which could lead to better treatments for hormone-related health issues and cancers, ultimately helping patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10615088 on NIH RePORTER |
What this research studies
This research investigates the dynamics and interactions of the cytochrome P450 19A1 enzyme, which plays a crucial role in the production of estrogen from androgens. By examining how this enzyme functions and interacts with various substrates, the research aims to uncover important insights that could improve drug development and treatment strategies for endocrine disorders and cancers. The study employs advanced methodologies to analyze the enzyme's behavior in different physiological contexts, which is essential for understanding its role in health and disease. Patients may benefit from the findings as they could lead to better-targeted therapies for conditions related to hormone imbalances.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with hormone-related cancers, gynecological disorders, or infertility issues.
Not a fit: Patients with conditions unrelated to hormone production or metabolism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for hormone-related cancers and endocrine disorders.
How similar studies have performed: Previous research has shown success in understanding similar cytochrome P450 enzymes, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Hackett, John C — Florida International University
- Study coordinator: Hackett, John C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.