Understanding how a key enzyme affects DNA viruses
Official title: Identifying a Critical Gatekeeper for DNA Virus Restriction
Funded at University of Texas Hlth Science Center · NIH-10826729 · Data updated 2026-11-12
This study is looking at how a special enzyme called APOBEC3B helps our body fight off DNA viruses, like the Epstein-Barr virus, and how some viruses try to escape its effects, with the hope that this research could lead to new treatments for viral infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $38,494 |
| NIH project number | 1F31AI181573-01 |
| Project ID | NIH-10826729 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by DNA virus-related conditions, such as those with Burkitt lymphoma or infections caused by Epstein-Barr virus.
✕Less likely to help
Patients with viral infections not related to DNA viruses or those without any viral infections may not receive benefits from this research.
What this research studies
This research investigates the role of the enzyme APOBEC3B in fighting DNA viruses, particularly focusing on its ability to mutate viral genomes. The study explores how certain viruses, like Epstein-Barr virus, have developed strategies to evade this enzyme's antiviral effects. By examining the localization of APOBEC3B within cells, the research aims to uncover the mechanisms that enhance its effectiveness against viral infections. Patients may benefit from insights that could lead to new antiviral therapies targeting these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral treatments that enhance the body's natural defenses against DNA viruses.
How similar studies have gone: Previous research has shown promising results in understanding the role of APOBEC enzymes in viral restriction, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Auerbach, Ashley a — University of Texas Hlth Science Center
- Study coordinator: Auerbach, Ashley a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.