Understanding how a key blood factor regulates clotting and bleeding
Structural Correlates of (Pro)Cofactor Function
This study is looking at a part of a protein called Factor V that helps your blood clot properly, and it aims to understand how this part works so we can find better treatments for people who have problems with bleeding or clotting.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10768830 on NIH RePORTER |
What this research studies
This research investigates the role of Factor V in the blood coagulation system, focusing on its B-domain, which is believed to regulate its functions in promoting clotting and preventing excessive bleeding. By using advanced techniques like atomic force microscopy, the study aims to uncover the structural features of the B-domain and how they influence Factor V's dual roles. The findings could lead to better understanding and potential therapies for conditions related to abnormal blood clotting or bleeding.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known blood coagulation disorders or those at risk for bleeding or thrombotic events.
Not a fit: Patients with stable coagulation profiles and no history of bleeding or thrombotic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from bleeding disorders or thrombosis.
How similar studies have performed: Previous research has shown promise in understanding coagulation factors, but this specific focus on the B-domain of Factor V is relatively novel.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Camire, Rodney M — Children's Hosp of Philadelphia
- Study coordinator: Camire, Rodney M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.