Understanding how a hormone affects food preferences after eating
Official title: Role of glucagon-like peptide-1 signaling in mediating sensory-specific satiety
Funded at University of Pennsylvania · NIH-10923839 · Data updated 2026-11-12
This study is looking at how a hormone called GLP-1 affects our brain's response to food after we eat, specifically how it makes us less interested in the food we've just had while making other foods seem more appealing, which could help us avoid overeating.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31DK137443-02 |
| Project ID | NIH-10923839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with overeating or obesity who may benefit from understanding the neuroendocrine factors influencing their eating behaviors.
✕Less likely to help
Patients who do not have issues with food intake or those with metabolic disorders unrelated to GLP-1 signaling may not benefit from this research.
What this research studies
This research investigates the role of glucagon-like peptide-1 (GLP-1) in how our brains respond to food after we've eaten. It focuses on sensory-specific satiety, which is the temporary decrease in desire for a food we've just consumed, while increasing the appeal of other foods. Using a rat model, the study will explore how GLP-1 signaling in the brain influences these eating behaviors and could help prevent overeating by regulating food intake. The findings could provide insights into the neuroendocrine mechanisms that control our eating habits.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing overeating and obesity by targeting specific brain signals.
How similar studies have gone: Previous research has shown promising results in understanding the role of GLP-1 in appetite regulation, indicating that this approach has potential for success.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Applebey, Sarah — University of Pennsylvania
- Study coordinator: Applebey, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.