Understanding how a high-fat diet affects blood cell development and aging
Official title: Investigating the Role of High Fat Diet in Hematopoiesis and Clonal Hematopoiesis
Funded at University of Michigan at Ann Arbor · NIH-11065215 · Data updated 2026-11-12
This study is looking at how eating a lot of fatty foods might affect the health of blood-forming stem cells in older adults, which could lead to changes in their genes and increase the risk of blood cancers, and it hopes to help identify those who might be at risk for these serious conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL177888-01 |
| Project ID | NIH-11065215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above, particularly those who may have dietary habits that include high-fat foods.
✕Less likely to help
Patients under the age of 65 or those without a high-fat diet may not receive direct benefits from this research.
What this research studies
This research investigates the impact of high-fat diets on the aging process of blood-forming stem cells, which are crucial for producing blood cells. It focuses on how these dietary habits may lead to genetic mutations in these cells, potentially increasing the risk of blood cancers, particularly in older adults. By analyzing blood samples from participants, the study aims to uncover the relationship between diet, genetic changes, and the health of the immune system as people age. This could help identify individuals at risk for developing serious blood-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to better dietary recommendations and preventive strategies for older adults to reduce their risk of blood cancers and improve overall health.
How similar studies have gone: Previous research has shown that dietary factors can influence blood cell health and mutation rates, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Campbell, Koral — University of Michigan at Ann Arbor
- Study coordinator: Campbell, Koral
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.