Understanding how a heart hormone receptor works
Official title: Structural Dynamics and Regulatory Mechanisms of Atrial Natriuretic Peptide Receptor
Funded at Weill Medical Coll of Cornell Univ · NIH-11028284 · Data updated 2026-11-12
This study is looking at how a hormone called atrial natriuretic peptide (ANP) interacts with its receptor in the body, which is important for keeping your heart and blood pressure healthy, and it could help us find new ways to treat heart disease and high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $535,213 |
| NIH project number | 1R01HL177433-01 |
| Project ID | NIH-11028284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hypertension or heart-related conditions who may benefit from new therapeutic approaches targeting the ANP pathway.
✕Less likely to help
Patients without cardiovascular issues or those not affected by hypertension may not receive direct benefits from this research.
What this research studies
This research investigates the atrial natriuretic peptide (ANP) and its receptor, which play crucial roles in heart health and blood pressure regulation. The study aims to uncover the structural changes that occur in the receptor when it binds to ANP, which is important for understanding how this hormone helps maintain cardiovascular balance. By using advanced techniques, researchers will explore the mechanisms that govern the receptor's function and its impact on heart and kidney health. This knowledge could lead to new treatments for conditions like hypertension and heart disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart disease and hypertension by enhancing our understanding of how the ANP receptor functions.
How similar studies have gone: Previous research has shown promising results in understanding similar hormonal pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Huang, Xin-Yun — Weill Medical Coll of Cornell Univ
- Study coordinator: Huang, Xin-Yun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.