Understanding how a gut hormone affects weight loss and health after surgery
The role of intestinal-derived FGF15/19 during obesity and rapid weight loss
This study is looking at how a hormone called FGF15/19 affects weight loss and possible side effects, like losing bone and muscle, in people who have weight loss surgery, so we can find better ways to help patients after their procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11098447 on NIH RePORTER |
What this research studies
This research investigates the role of the gut hormone FGF15/19 in the context of obesity and weight loss, particularly following bariatric surgery. It aims to understand how this hormone influences weight loss outcomes and potential complications, such as bone and muscle loss, in patients undergoing procedures like Vertical Sleeve Gastrectomy. By using a specialized mouse model, the study will explore the biological mechanisms at play and how they may differ in individuals who have undergone surgery. The findings could provide insights into improving patient care and outcomes after weight loss surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults, particularly veterans, who are considering or have undergone bariatric surgery.
Not a fit: Patients who are not undergoing bariatric surgery or those with conditions unrelated to obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for patients undergoing bariatric surgery, potentially reducing complications and improving overall health outcomes.
How similar studies have performed: Other research has shown promising results in understanding the role of gut hormones in weight management, suggesting that this approach could yield significant insights.
Where this research is happening
Ann Arbor, United States
- Veterans Health Administration — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Kramer, Nadejda Bozadjieva — Veterans Health Administration
- Study coordinator: Kramer, Nadejda Bozadjieva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.