Understanding how a genetic variant affects immune response
Official title: New insight into innate immune regulation through mechanistic studies of a novel oligoadenylate synthetase-like (OASL) gain-of-function variant
Funded at Emory University · NIH-11101111 · Data updated 2026-11-12
This study is looking at a genetic change that affects a protein in your immune system, which might make you more prone to infections, and the goal is to learn more about how this works so we can find better treatments for people with immune problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $195,625 |
| NIH project number | 5R21AI175846-02 |
| Project ID | NIH-11101111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inborn errors of immunity, particularly those experiencing recurrent infections or autoimmune conditions.
✕Less likely to help
Patients without genetic immune deficiencies or those not affected by immune-related conditions may not benefit from this research.
What this research studies
This research investigates a specific genetic variant that impacts the innate immune system, particularly focusing on a protein called OASL. The study aims to understand how a mutation in this protein can lead to increased sensitivity to infections and other immune-related issues. By examining the molecular mechanisms involved, researchers hope to uncover new insights into how the immune system functions and how it can be regulated. This could ultimately lead to better treatments for patients with immune deficiencies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with inherited immune disorders.
How similar studies have gone: Previous research has shown success in understanding immune deficiencies through genetic studies, making this approach promising.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Conn, Graeme L — Emory University
- Study coordinator: Conn, Graeme L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.