Understanding how a gene mutation affects social behavior in children with autism
Official title: Cellular mechanism of Arid1b haploinsufficiency-associated social deficit
Funded at Kent State University · NIH-10736386 · Data updated 2026-11-12
This study is looking at how a gene called ARID1B might affect social skills and behaviors in autism, using mice to learn more about what happens in the brain, with the hope of finding new ways to help children with autism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kent State University NIH-funded |
| Lab location | 1 site (Kent, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $557,050 |
| NIH project number | 1R56MH130599-01A1 |
| Project ID | NIH-10736386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with autism spectrum disorder.
✕Less likely to help
Patients who do not have autism spectrum disorder or those outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research investigates the role of the ARID1B gene in autism spectrum disorder (ASD), particularly how its deficiency affects social interactions and behaviors. Using a mouse model that mimics human ASD traits, the study aims to uncover the cellular mechanisms behind these social deficits. By examining brain circuits involved in social behavior and potential mitochondrial dysfunction, the research seeks to identify new therapeutic targets for ASD. The findings could lead to better understanding and treatment options for children affected by this condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving social behavior in children with autism.
How similar studies have gone: Previous studies have shown promising results in understanding genetic contributions to autism, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Kent State University
Kent, United States Active
Researchers
- Principal investigator: Kim, Woo-Yang — Kent State University
- Study coordinator: Kim, Woo-Yang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.