Understanding how a gene mutation affects movement and speech in a type of dementia.
Official title: Striatal Contribution to the Motor Symptoms and Aphasia in GRN-FTD
Funded at University of Florida · NIH-10992795 · Data updated 2026-11-12
This study is looking at how certain genetic changes related to frontotemporal dementia affect movement and speech by using mice that have similar mutations, with the goal of finding new ways to help people with this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $305,000 |
| NIH project number | 1R03AG087418-01A1 |
| Project ID | NIH-10992795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with frontotemporal dementia, particularly those with GRN mutations.
✕Less likely to help
Patients with other forms of dementia or those without GRN mutations may not benefit from this research.
What this research studies
This research investigates the impact of GRN mutations on motor symptoms and language difficulties in patients with frontotemporal dementia (FTD). Using mouse models that mimic human GRN mutations, the study aims to explore how these genetic changes affect brain circuits, particularly in the basal ganglia, which are crucial for movement and speech. By examining the behavior and brain activity of these mice, researchers hope to uncover the underlying mechanisms that lead to the symptoms observed in FTD patients. The findings could provide insights into potential therapeutic targets for improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from frontotemporal dementia.
How similar studies have gone: Previous research has shown promising results in understanding genetic contributions to neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Li, Yuqing — University of Florida
- Study coordinator: Li, Yuqing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.