Understanding how a gene mutation affects appetite control
Official title: Neural Mechanism of Impaired Satiation After Magel2 Mutation
Funded at University of Arizona · NIH-10947972 · Data updated 2026-11-12
This study is looking at how changes in a specific gene can affect the brain's ability to feel full, which is important for people with Prader-Willi Syndrome, and it hopes to find new ways to help manage their appetite.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $223,446 |
| NIH project number | 1R21HD116113-01 |
| Project ID | NIH-10947972 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Prader-Willi Syndrome or Shafer-Young Syndrome, particularly those experiencing issues with appetite regulation.
✕Less likely to help
Patients without genetic mutations affecting appetite regulation or those not diagnosed with related syndromes may not benefit from this research.
What this research studies
This research investigates the neural mechanisms behind impaired feelings of fullness in individuals with mutations in the Magel2 gene, which are linked to conditions like Prader-Willi Syndrome. The study focuses on how these mutations affect specific neurons in the brain that are responsible for processing signals related to satiation, particularly the hormone cholecystokinin (CCK). By using animal models, the researchers aim to uncover the pathways that lead to excessive eating behaviors associated with these genetic disorders. The findings could provide insights into potential therapeutic targets for managing appetite in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for individuals with genetic conditions that cause insatiable appetite, improving their quality of life.
How similar studies have gone: Previous studies have shown success in understanding appetite regulation through similar neural circuit investigations, indicating a promising avenue for this research.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Cai, Haijiang — University of Arizona
- Study coordinator: Cai, Haijiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.