Understanding how a gene called LRRK2 affects brain cells
Mechanisms of LRRK2 Mediated Neurotoxicity
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11136426
This research explores how changes in a gene called LRRK2 contribute to brain cell damage in conditions like Parkinson's and related dementias.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11136426 on ClinicalTrials.gov |
What this research studies
Parkinson's disease and related conditions, known as Lewy body diseases, are significant causes of dementia that can begin earlier in life than Alzheimer's. Many individuals carry specific changes in a gene called LRRK2, which can increase their risk for these conditions. Our previous work showed that LRRK2 influences how certain proteins clump together in brain cells and is also active in immune cells within the brain during disease. This project will closely examine how LRRK2 interacts with other proteins called Rab, focusing on a unique enzymatic process. By understanding these detailed interactions, we hope to uncover new ways to address the brain cell damage seen in these diseases.
Who could benefit from this research
Good fit: This foundational research aims to help individuals living with Parkinson's disease, Lewy body dementias, or those who carry LRRK2 gene mutations.
Not a fit: Patients seeking immediate treatment options may not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat or prevent the brain cell damage seen in Parkinson's and related dementias.
How similar studies have performed: This is a renewal of a successful prior grant, building on previous findings while exploring novel aspects of LRRK2 function.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEST, ANDREW B — DUKE UNIVERSITY
- Study coordinator: WEST, ANDREW B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome