Understanding how a gene called BIN1 affects Alzheimer's disease
The role of Alzheimer's disease GWAS risk factor BIN1 in tau neuropathology and propagation in vivo
This project explores how a specific gene, BIN1, influences the development and spread of tau protein changes linked to Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11291349 on NIH RePORTER |
What this research studies
We are looking into how a gene called BIN1, which is a major risk factor for late-onset Alzheimer's disease, affects the brain. This gene seems to play a role in how harmful tau proteins, which are a hallmark of Alzheimer's, spread throughout the brain. Our work uses special animal models to observe these changes and understand how BIN1 influences the disease's progression. We've seen some interesting, complex results where BIN1 loss can both worsen and protect certain parts of the brain from tau damage. By understanding this better, we hope to uncover new ways to fight Alzheimer's.
Who could benefit from this research
Good fit: Patients with a family history of Alzheimer's disease or those concerned about their risk may find this research relevant to future treatment options.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this foundational research.
Why it matters
Potential benefit: Successfully understanding BIN1's role could open doors to developing new treatments that slow or stop the progression of Alzheimer's disease.
How similar studies have performed: While some lab studies suggest BIN1's role in tau, direct evidence in living systems for its influence on tau pathology propagation is still being established.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Thinakaran, Gopal — University of South Florida
- Study coordinator: Thinakaran, Gopal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.