Understanding how a gene called ALDH1L1 affects glycine levels
Mechanistic and metabolomic underpinnings of ALDH1L1 polymorphisms in the regulation of glycine metabolism
This project aims to understand how a specific gene, ALDH1L1, and its variations influence the body's use of folate and glycine, especially in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11139542 on NIH RePORTER |
What this research studies
Our bodies use a key enzyme called ALDH1L1 to process folate, which is important for many functions, including making new cells and managing other important substances. We've found that if this enzyme isn't working correctly, it can lead to a shortage of folate and affect how the body handles glycine, an amino acid. This project looks at common genetic differences in the ALDH1L1 gene and how these variations might change glycine levels in children. By studying these genetic differences, we hope to learn more about how they impact metabolism and potentially contribute to health conditions.
Who could benefit from this research
Good fit: This research is relevant to children, particularly those of Hispanic descent, who may have specific genetic variations in the ALDH1L1 gene.
Not a fit: Patients whose metabolic issues are unrelated to folate or glycine metabolism, or who do not have the specific ALDH1L1 genetic variations being studied, may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could help us understand why some children have altered glycine levels, potentially leading to new ways to support their metabolic health.
How similar studies have performed: Previous work in mice and initial findings in human children have shown a link between the ALDH1L1 gene and glycine levels, suggesting this approach has a promising foundation.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Krupenko, Sergey a — Univ of North Carolina Chapel Hill
- Study coordinator: Krupenko, Sergey a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.