Understanding how a gene affects eye health during herpes infections
Autophagic Regulation of Eye Interaction
This study is looking at how a gene called optineurin (OPTN) helps protect the eye and nerves from damage caused by the herpes virus, with the hope of finding new ways to prevent issues like blindness and long-lasting inflammation for people affected by this virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11050184 on NIH RePORTER |
What this research studies
This research investigates the role of the optineurin (OPTN) gene in protecting the cornea and sensory nerves from damage caused by herpes simplex virus type-1 (HSV-1) infections. By studying how OPTN influences immune responses and nerve function, the research aims to uncover new cellular mechanisms that could prevent complications like blindness and chronic inflammation. The approach includes using experimental models to observe the effects of OPTN dysfunction on nerve health and immune responses during HSV-1 infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced HSV-1 infections or related eye complications.
Not a fit: Patients with eye conditions unrelated to HSV-1 or those who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect eye health and prevent blindness in patients affected by HSV-1.
How similar studies have performed: Previous research has shown promising results in understanding the role of genes in viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Shukla, Deepak — University of Illinois at Chicago
- Study coordinator: Shukla, Deepak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.