Understanding how a fungus affects immune response in patients with weakened immune systems
DAP12 and the host response to cryptococcosis
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10876414
This study is looking at how the fungus Cryptococcus neoformans interacts with the immune system in people with weakened immune systems, like those with HIV/AIDS, cancer, or who have had organ transplants, to find new ways to help their bodies fight off infections better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10876414 on ClinicalTrials.gov |
What this research studies
This research investigates the interaction between the fungus Cryptococcus neoformans and the immune system, particularly in patients with compromised immunity such as those with HIV/AIDS, cancer, or organ transplants. The study focuses on how the fungus evades the immune response by manipulating inflammatory monocytes, which are crucial for fighting infections. By exploring the role of a specific protein called DAP12, the research aims to uncover new strategies to enhance the immune response and improve treatment outcomes for cryptococcosis. The findings could lead to better antifungal therapies and improved survival rates for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with weakened immune systems, particularly those diagnosed with HIV/AIDS, undergoing cancer treatment, or who have received organ transplants.
Not a fit: Patients with strong immune systems or those not at risk for cryptococcosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for cryptococcosis, significantly reducing mortality rates in vulnerable patient populations.
How similar studies have performed: Previous research has shown promising results in understanding immune evasion by pathogens, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEUNG, LENA J — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: HEUNG, LENA J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.