Understanding how a fungus adapts to the body to cause disease
Genetic and mechanistic analysis of carbon dioxide tolerance in Cryptococcus pathogenesis
This research explores how a specific fungus, Cryptococcus neoformans, adapts to the human body's environment, particularly in people with HIV/AIDS, to cause serious infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11123780 on NIH RePORTER |
What this research studies
Cryptococcus neoformans causes dangerous fungal infections, especially in people with weakened immune systems like those with HIV/AIDS. Only certain strains of this fungus can cause disease by successfully adapting to the human body's internal conditions. Researchers have discovered that the fungus's ability to tolerate the body's carbon dioxide levels is a key factor in its survival and ability to cause illness. This project aims to uncover the specific genetic and molecular ways the fungus manages carbon dioxide, which helps it become harmful. By understanding these mechanisms, we hope to find new ways to stop these life-threatening infections.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals susceptible to Cryptococcus neoformans infections, such as those living with HIV/AIDS.
Not a fit: Patients not at risk for Cryptococcus neoformans infections would likely not see direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or prevention strategies for serious fungal infections, especially for individuals with weakened immune systems like those with HIV/AIDS.
How similar studies have performed: Previous work by this team has identified carbon dioxide tolerance as a critical factor for the fungus's ability to cause disease, building upon existing knowledge of fungal virulence.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Krysan, Damian J — University of Iowa
- Study coordinator: Krysan, Damian J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.