Understanding how a fungus adapts to human body conditions
Official title: Define the molecular bases for cryptococcal adaptation to host conditions by the RAM pathway
Funded at University of Georgia · NIH-10796892 · Data updated 2026-11-12
This study is looking at how the fungus Cryptococcus neoformans changes to survive in the human body, especially in people with AIDS, so that we can find better ways to treat infections caused by it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $226,500 |
| NIH project number | 5R21AI175054-02 |
| Project ID | NIH-10796892 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with AIDS who are at risk of developing cryptococcal infections.
✕Less likely to help
Patients who do not have AIDS or are not at risk for cryptococcal infections may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the fungus Cryptococcus neoformans adapts to the human body, particularly focusing on its ability to survive in high temperatures and elevated CO2 levels. By studying the RAM pathway, which is crucial for the fungus's growth and virulence, researchers aim to uncover how these adaptations contribute to the severity of cryptococcal infections, especially in AIDS patients. The study employs various experimental models, including mouse models, to assess the impact of specific genetic disruptions on the fungus's ability to thrive in host-like environments. This knowledge could lead to improved treatment strategies for cryptococcal infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antifungal therapies for cryptococcal infections, potentially saving lives.
How similar studies have gone: Previous research has shown that understanding fungal adaptation mechanisms can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Lin, Xiaorong — University of Georgia
- Study coordinator: Lin, Xiaorong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.