Understanding how A. fumigatus causes infections
Transcriptional networks governing A. fumigatus virulence
['FUNDING_R01'] · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · NIH-10894154
This study is looking at how a specific gene in the fungus Aspergillus fumigatus helps it cause infections in people, with the hope that understanding this could lead to better treatments and tests for those infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER (nih funded) |
| Locations | 1 site (TORRANCE, UNITED STATES) |
| Trial ID | NIH-10894154 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that contribute to the virulence of the fungus Aspergillus fumigatus, which can cause serious infections in humans. The team is focusing on a specific gene regulator called WrpA, which appears to play a crucial role in the fungus's ability to survive in the human body and cause disease. By using advanced techniques like RNA sequencing, the researchers aim to identify how WrpA influences other genes related to infection and virulence. This knowledge could lead to the development of new treatments and diagnostic tools for infections caused by this fungus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for invasive aspergillosis, such as those with weakened immune systems or underlying lung conditions.
Not a fit: Patients who are not at risk for Aspergillus infections or those with other unrelated health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and diagnostics for patients suffering from invasive Aspergillus infections.
How similar studies have performed: Other research has shown promise in identifying genetic factors in fungal virulence, suggesting that this approach could yield valuable insights.
Where this research is happening
TORRANCE, UNITED STATES
- LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER — TORRANCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FILLER, SCOTT G — LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
- Study coordinator: FILLER, SCOTT G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.