Understanding how a dengue vaccine protects against the virus
Mechanisms of Protection and Durability for a Live Attenuated Tetravalent Dengue Vaccine
['FUNDING_U01'] · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · NIH-10995312
This study is looking at a new dengue vaccine that aims to protect against all four types of the virus, and it's for both kids and adults who live in areas where dengue is common, to see how well it helps the body build lasting immunity without causing serious illness.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VERMONT & ST AGRIC COLLEGE (nih funded) |
| Locations | 1 site (BURLINGTON, UNITED STATES) |
| Trial ID | NIH-10995312 on ClinicalTrials.gov |
What this research studies
This research investigates a live attenuated tetravalent dengue vaccine designed to provide protection against all four serotypes of the dengue virus. The study focuses on understanding how the vaccine generates long-lasting immunity without increasing the risk of severe disease. Researchers will evaluate the immune responses in both dengue-naïve individuals and those previously exposed to the virus, particularly in children and adults in endemic areas. The goal is to identify the mechanisms that contribute to effective and durable protection following vaccination.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults living in dengue-endemic areas or those who have not been previously exposed to the dengue virus.
Not a fit: Patients who have already developed immunity to dengue through previous infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a highly effective dengue vaccine that protects individuals from severe illness caused by the virus.
How similar studies have performed: Previous research has shown promise in developing tetravalent dengue vaccines, but this specific approach is focused on understanding the mechanisms of protection, making it a novel investigation.
Where this research is happening
BURLINGTON, UNITED STATES
- UNIVERSITY OF VERMONT & ST AGRIC COLLEGE — BURLINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIEHL, SEAN A. — UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- Study coordinator: DIEHL, SEAN A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.