Understanding how a dangerous bacteria fights off treatments
Global Circuitry that Controls Acinetobacter Resistance and Virulence
This project looks at how a very resistant bacteria called Acinetobacter baumannii protects itself from antibiotics and the body's defenses, hoping to find new ways to treat serious infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11124005 on NIH RePORTER |
What this research studies
Acinetobacter baumannii is a serious 'superbug' that is very difficult to treat because it resists many antibiotics. This bacteria has a unique protective outer layer that helps it fight off both medicines and your body's immune system. Researchers are focusing on a special control system within the bacteria, called BfmRS, which helps it maintain this protection and cause disease. By learning how this system works and what triggers it, we hope to discover new ways to weaken the bacteria and make it treatable.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage.
Not a fit: Patients whose infections are caused by bacteria other than Acinetobacter baumannii would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for severe Acinetobacter baumannii infections, offering hope for patients who currently have limited options.
How similar studies have performed: This research focuses on a unique bacterial control system, suggesting a novel approach to understanding and combating antibiotic resistance.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Geisinger, Edward — Northeastern University
- Study coordinator: Geisinger, Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.