Understanding how a common virus affects brain cancer treatments
Defining the role of cytomegalovirus in glioblastoma therapies
This study is looking at how a virus called cytomegalovirus (CMV) might affect the growth of glioblastoma, a tough type of brain cancer, using mice to help understand how it could change treatment results for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11045073 on NIH RePORTER |
What this research studies
This research investigates the role of cytomegalovirus (CMV) in glioblastoma, a type of aggressive brain cancer. By using a mouse model that mimics human disease, the researchers aim to uncover how CMV influences tumor growth and response to therapies. The study will explore the mechanisms by which CMV may affect treatment outcomes, particularly focusing on immune responses and blood vessel formation in tumors. Patients may benefit from insights that could lead to more effective treatment strategies targeting both the virus and the tumor.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those who are CMV seropositive.
Not a fit: Patients with glioblastoma who are CMV negative or those with other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for glioblastoma patients by targeting the underlying viral influences on tumor behavior.
How similar studies have performed: Other studies have shown promising results in targeting CMV in glioblastoma, indicating that this approach has potential based on previous findings.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Lawler, Sean Edward — Brown University
- Study coordinator: Lawler, Sean Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.