Understanding how a chromatin regulator keeps gene expression correct
Official title: Mechanism of Kumgang/Mi-2 complex for transcriptional fidelity
Funded at Cornell University · NIH-11420761 · Data updated 2026-11-12
This project looks at how specific proteins keep genes turned on or off correctly to prevent cancer-related misexpression.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | July 21, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $424,158 |
| NIH project number | 1R35GM165297-01 |
| Project ID | NIH-11420761 on NIH RePORTER |
Who could benefit from this research
✓Could help
No specific patient participation is described in the grant; the work is basic science in cellular and genomic contexts.
✕Less likely to help
Direct patient benefits are not part of the current plan, as it focuses on fundamental mechanisms in model systems.
What this research studies
Scientists will study how chromatin is bundled in cells to stop inappropriate transcription, focusing on how Kumgang and Mi-2 complexes control gene repression. The research will map where these regulators attach in the genome and how they change the patterns of gene activity during development and in cancer. By using model systems and human-relevant contexts, the team aims to reveal core principles of transcriptional control that could inform new therapeutic strategies. The work is designed to build a clearer picture of why some genes go rogue and how cells maintain their identity. Over five years, findings could point to targets for correcting faulty gene expression in diseases.
Why it matters
Potential benefit: Better understanding of transcriptional repression could lead to new approaches to prevent or treat cancers driven by misregulated genes.
How similar studies have gone: Previous studies have shown that chromatin regulators like Mi-2 complex influence gene expression patterns in development and cancer, supporting the potential value of this line of work.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Kim, Jongmin — Cornell University
- Study coordinator: Kim, Jongmin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.