Understanding how a chloride transporter helps heal gut tissues
Official title: A Novel Role of Apical Chloride Transporter (DRA) in Mucosal Tissue Repair
Funded at Jesse Brown VA Medical Center · NIH-10927676 · Data updated 2026-11-12
This study is looking at how a special protein called DRA helps heal the gut in people with inflammatory bowel diseases like Crohn's and ulcerative colitis, to find new ways to improve treatment and reduce symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006626-01 |
| Project ID | NIH-10927676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis, particularly those experiencing chronic symptoms.
✕Less likely to help
Patients with gastrointestinal conditions unrelated to inflammatory bowel diseases may not benefit from this research.
What this research studies
This research investigates the role of a specific chloride transporter, known as DRA, in the healing processes of the gastrointestinal tract, particularly in patients suffering from inflammatory bowel diseases like Crohn's disease and ulcerative colitis. By studying the molecular mechanisms involved in tissue repair and inflammation, the research aims to uncover how deficiencies in this transporter can lead to increased gut permeability and chronic symptoms. The approach includes analyzing genetic data from animal models to understand the impact of DRA on gut health and recovery after inflammation. This could lead to new therapeutic strategies for managing these challenging conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with inflammatory bowel diseases, potentially reducing symptoms and enhancing tissue repair.
How similar studies have gone: Previous research has shown promising results in understanding the role of chloride transporters in gut health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Kumar, Anoop — Jesse Brown VA Medical Center
- Study coordinator: Kumar, Anoop
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.