Understanding how a cellular process can help yeast live longer
Official title: Discovering how autophagy is sufficient to extend yeast replicative lifespan
Funded at Weill Medical Coll of Cornell Univ · NIH-11060925 · Data updated 2026-11-12
This study is looking at how a process that helps cells clean up damaged parts can help yeast live longer, and by figuring this out, researchers hope to find ways that might help people age healthier too.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $524,263 |
| NIH project number | 5R01AG079883-03 |
| Project ID | NIH-11060925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals interested in aging and longevity, particularly those with age-related conditions.
✕Less likely to help
Patients with acute or terminal conditions unrelated to aging may not receive benefit from this research.
What this research studies
This research investigates the role of autophagy, a cellular process that helps remove damaged components, in extending the lifespan of yeast cells. By studying how various interventions, such as medications and dietary changes, affect yeast's ability to replicate, the researchers aim to uncover the molecular mechanisms behind aging. The findings could provide insights into how similar processes might be applied to other organisms, including humans, to promote healthier aging. Patients may benefit from understanding these mechanisms as they could lead to new anti-aging therapies.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in anti-aging therapies that improve healthspan and longevity in humans.
How similar studies have gone: Other research has shown promising results in extending lifespan through similar cellular mechanisms, indicating potential for success in this area.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Tyler, Jessica K — Weill Medical Coll of Cornell Univ
- Study coordinator: Tyler, Jessica K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.