Understanding how a cellular metabolite affects HIV-1 infection and replication.
Official title: Elucidating the role of IP6 in HIV-1 assembly, maturation, and infection.
Funded at University of Iowa · NIH-11320933 · Data updated 2026-11-12
This study is looking at how a substance called inositol hexakisphosphate (IP6) affects the way the HIV-1 virus grows and changes, with the hope of finding new ways to treat HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 4R00AI174891-02 |
| Project ID | NIH-11320933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may be experiencing treatment resistance or virologic failure.
✕Less likely to help
Patients who are not living with HIV or those who have not been affected by treatment resistance may not benefit from this research.
What this research studies
This research investigates the role of inositol hexakisphosphate (IP6) in the HIV-1 lifecycle, focusing on how it influences the assembly and maturation of the virus. By examining how IP6 interacts with HIV-1 components, the research aims to uncover mechanisms that could lead to the development of new antiviral therapies. The approach includes using a forced evolution technique to study how HIV-1 adapts when IP6 binding is disrupted. This could provide insights into improving current treatments and developing novel inhibitors.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral therapies that enhance the effectiveness of existing HIV treatments.
How similar studies have gone: Previous research has shown promise in targeting viral assembly and maturation processes, suggesting that this approach could yield significant advancements in HIV treatment.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Kleinpeter, Alex — University of Iowa
- Study coordinator: Kleinpeter, Alex
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.