Understanding how a cancer protein is modified in clear cell sarcoma
Elucidation of New Phosphorylation Site of the EWS/ATF1 Fusion Oncoprotein in Clear Cell Sarcoma
This study is looking into how a specific protein involved in clear cell sarcoma, a rare cancer that mainly affects young adults, works and changes, with the hope of finding new ways to treat this disease.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10670347 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind clear cell sarcoma, a rare and aggressive cancer that primarily affects young adults. It focuses on the EWS/ATF1 fusion oncoprotein, which is formed from gene fusions and plays a critical role in the cancer's development. The researchers aim to identify new phosphorylation sites that regulate the function of this oncoprotein, which could lead to better understanding and treatment options. By studying how these modifications affect cancer cell behavior, the research seeks to uncover potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults diagnosed with clear cell sarcoma or those with related malignancies.
Not a fit: Patients with other types of cancers or those not diagnosed with clear cell sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for clear cell sarcoma, improving outcomes for patients.
How similar studies have performed: While research on EWS/ATF1 has been conducted, the identification of new phosphorylation sites in this context is a novel approach that has not been extensively tested.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Tsuji, Yoshiaki — North Carolina State University Raleigh
- Study coordinator: Tsuji, Yoshiaki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.