Understanding how a brain structure affects attention and behavior
Official title: Deciphering the Thalamic Reticular Functions of Phospholamban
Funded at University of Dayton · NIH-10874021 · Data updated 2026-11-12
This study is looking at a part of the brain that helps with how we process senses, pay attention, and sleep, to see how a specific protein affects its function, which could help us understand and improve treatments for conditions like autism and ADHD.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Dayton NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project start | July 15, 2024 |
| Project end | July 14, 2027 |
| Funding year | 2024 |
| Award (this year) | $413,681 |
| NIH project number | 1R15MH136640-01 |
| Project ID | NIH-10874021 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD).
✕Less likely to help
Patients with conditions unrelated to neurodevelopmental disorders may not receive benefit from this research.
What this research studies
This research investigates the thalamic reticular nucleus (TRN), a brain region that plays a crucial role in sensory processing, attention, and sleep. The study focuses on how a protein called phospholamban (PLN) influences the functioning of TRN neurons, particularly in relation to neurodevelopmental disorders like autism and ADHD. By examining the effects of PLN on calcium handling in these neurons, the research aims to uncover mechanisms that could lead to better understanding and treatment of related behavioral issues. Patients may benefit from insights gained about how TRN dysfunction contributes to their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing attention and behavioral disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of calcium handling in brain function, suggesting potential for breakthroughs in this area.
Where this research is happening
-
University of Dayton
Dayton, United States Active
Researchers
- Principal investigator: Pitychoutis, Pothitos — University of Dayton
- Study coordinator: Pitychoutis, Pothitos
Related research
Other NIH-funded projects on the same topics.
-
Computer help to spot lung nodules on children's CT scans
This project will build a computer tool to help doctors find lung nodules on chest CT scans for children and young adults.
-
Detecting lung nodules in children's CT scans using advanced technology
This study is working on a smart computer program that helps doctors find tiny lumps in kids' lungs on CT scans, making it easier to catch any signs of cancer early and improve treatment for young patients.
-
Understanding how the Drosophila eye develops its top and bottom structures
This study looks at how certain genes help shape the top and bottom parts of a fruit fly's eye, which could help us learn more about eye development and related issues in humans.
-
Advanced 3D imaging technology for observing nanoscale biological structures
This study is exploring a new 3D imaging tool that helps scientists see tiny biological structures more clearly, which could lead to better ways to diagnose and treat diseases that affect you.
-
Creating assistive devices for individuals with disabilities through collaboration
This study is all about creating helpful devices for kids and adults with disabilities, so they can do everyday tasks more easily and enjoy life in their communities, with occupational therapists and engineers working together to make sure these devices fit each person's unique needs.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.