Understanding how a brain structure affects attention and behavior
Deciphering the Thalamic Reticular Functions of Phospholamban
['FUNDING_R15'] · UNIVERSITY OF DAYTON · NIH-10874021
This study is looking at a part of the brain that helps with how we process senses, pay attention, and sleep, to see how a specific protein affects its function, which could help us understand and improve treatments for conditions like autism and ADHD.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF DAYTON (nih funded) |
| Locations | 1 site (DAYTON, UNITED STATES) |
| Trial ID | NIH-10874021 on ClinicalTrials.gov |
What this research studies
This research investigates the thalamic reticular nucleus (TRN), a brain region that plays a crucial role in sensory processing, attention, and sleep. The study focuses on how a protein called phospholamban (PLN) influences the functioning of TRN neurons, particularly in relation to neurodevelopmental disorders like autism and ADHD. By examining the effects of PLN on calcium handling in these neurons, the research aims to uncover mechanisms that could lead to better understanding and treatment of related behavioral issues. Patients may benefit from insights gained about how TRN dysfunction contributes to their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD).
Not a fit: Patients with conditions unrelated to neurodevelopmental disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing attention and behavioral disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of calcium handling in brain function, suggesting potential for breakthroughs in this area.
Where this research is happening
DAYTON, UNITED STATES
- UNIVERSITY OF DAYTON — DAYTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PITYCHOUTIS, POTHITOS — UNIVERSITY OF DAYTON
- Study coordinator: PITYCHOUTIS, POTHITOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.