Understanding how a brain factor influences bone and fat metabolism
Official title: Determining the Role of Brain-Derived CCN3 in Bone and Marrow Fat Metabolism
Funded at University of California, San Francisco · NIH-11136316 · Data updated 2026-11-12
This study is looking at how a brain protein called CCN3 influences bone growth and fat storage in the bone marrow, which could help us find better ways to treat age-related issues like diabetes and obesity.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $170,748 |
| NIH project number | 5K08DK133674-02 |
| Project ID | NIH-11136316 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those experiencing metabolic issues such as obesity or diabetes.
✕Less likely to help
Patients who are younger and do not have metabolic disorders or bone health issues may not benefit from this research.
What this research studies
This research investigates the role of a brain-derived factor called CCN3 in regulating bone formation and fat metabolism in the bone marrow. The study will utilize both laboratory and animal models to explore how varying levels of CCN3 affect these processes. By examining the interactions between skeletal health and metabolic functions, the research aims to uncover new insights that could lead to improved treatments for age-related conditions like diabetes and obesity.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing bone health and metabolic disorders in aging populations.
How similar studies have gone: Previous research has shown promising results in understanding the role of brain-derived factors in metabolic processes, suggesting potential for success in this area.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Babey, Muriel — University of California, San Francisco
- Study coordinator: Babey, Muriel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.