Understanding how a brain barrier regulates its permeability
Investigations of cAMP-dependent brain-barrier permeability in choroid plexus
['FUNDING_FELLOWSHIP'] · BOSTON CHILDREN'S HOSPITAL · NIH-10907528
This study is looking at a part of the brain called the choroid plexus, which helps protect the brain, to see how a messenger called cAMP affects its ability to keep things out, and it’s for anyone interested in understanding how brain health can be improved in conditions like brain disorders or injuries.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10907528 on ClinicalTrials.gov |
What this research studies
This research investigates the choroid plexus, a critical brain barrier that can influence damage in brain disorders and trauma. By using advanced imaging technology, the study aims to explore how the intracellular messenger cAMP affects the permeability of this barrier at the cellular level. The researchers will examine how neurotransmitters interact with specific receptors to regulate barrier integrity, which is essential for maintaining brain health. This work could lead to new insights into how brain barriers function and how they can be targeted in various brain conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing brain disorders or trauma that may affect the blood-brain barrier.
Not a fit: Patients with conditions unrelated to brain barrier permeability or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for brain disorders by enhancing our understanding of brain barrier function.
How similar studies have performed: Other research has shown promising results in understanding brain barrier mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FIGUEROA VELEZ, DARIO XAVIER — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: FIGUEROA VELEZ, DARIO XAVIER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.